This simple test could one day tell you if you have cancer

This simple test could one day tell you if you have cancer

"The test to detect cancerous cells can be performed in 10 minutes". The researchers called this methylation pattern the "methylation landscape", or "methylscape". The structure is the same in DNA from samples of breast, prostate and bowel cancers, as well as lymphoma.

The development was made possible after they discovered that placing the cancerous DNA in a solution caused it to fold up into 3D structures.

The technique can also be used on tissue biopsies.

Currently, the researchers are working with the university's commercialization company, UniQuest, to develop and license the technology; they plan to assess its use in detecting different cancer types across all stages from different bodily fluids as well as in gauging responses to treatment.

Sina said: "It works for tissue-derived genomic DNA and blood-derived circulating free DNA".

He said cancer cells released their DNA into blood plasma when they died.

And so, Sina and colleagues compared the epigenetic patterns on the genomes of cancer cells to those of healthy cells, specifically focusing on patterns of methyl groups.

"Virtually every piece of cancerous DNA we examined had this highly predictable pattern", Professor Trau said.

"This makes it bind to the gold nanoparticles, and it's much stronger binding than the normal DNA is".

Sandra Oh and Andy Samberg to co-host 2019 Golden Globes
The Golden Globes led NBC to the nightlong win in total viewers despite National Football League playoff competition. She won a Golden Globe in 2006 for actress in a supporting role in a series for " Grey's Anatomy ".

Denver Broncos think WR Emmanuel Sanders tore Achilles
Sanders, in his ninth National Football League season and fifth with Denver, is the team's leading receiver by far. Sutton is now the team's leading receiver among active players with 558 yards and three touchdowns.

Fresh witness evidence leads to arrest of Chris Dawson over wife's disappearance
He's been taken to the Southport Courthouse where NSW detectives will apply for his extradition at his first court appearance. She said her client had co-operated with detectives in the past and was happy to comply with any bail conditions imposed.

So, the researchers developed a test that exploits this ability of cancer DNA to stick to gold. This requires a tiny amount of purified DNA to be mixed with some drops of gold particle solution.

The test also works for electrochemical detection - when the DNA is attached onto flat gold electrodes.

These instantly change color depending on whether the 3D nanostructures of cancer DNA are present.

"This led to the creation of affordable and portable detection devices that could eventually be used as a diagnostic tool, possibly with a mobile phone", said Professor Matt Trau, one of the lead researchers on the project.

For this test to work properly the DNA must be pure. This new technology, which was shown to be up to 90 percent accurate in testing with normal DNA and 200 human cancer samples, could be turned into portable detection tools down the line. Accuracy is important to ensure there are fewer false positives - wrongly detecting cancer when there is none.

It is based on a process known as epigenetics - the attachment of a chemical tag known as a methyl group to DNA. Professor Trau said that the next step would be to start clinical trials to hone the test.

Although it is far too early to know how useful the discovery could be as a clinical tool, scientists said it was an exciting advance in the understanding of cancer.

"You can detect it by eye - it's as simple as that", study senior author Matt Trau, a professor and senior group leader at the University of Queensland's Australian Institute for Bioengineering and Nanotechnology, said in a statement.

Related Articles