Mike Hughes intercepts Jimmy Garoppolo for pick-six

Mike Hughes intercepts Jimmy Garoppolo for pick-six

While Cousins twice connected on tight-window throws for touchdowns for the Vikings, most of Garoppolo's similar throws in traffic went Minnesota's way.

The throws Cousins made in tight coverage at important times were on target.

Jimmy Garoppolo is human, after all.

"It always does. That's every team", 49ers coach Kyle Shanahan said Monday, one day after his team's 24-16 loss at Minnesota on the first Sunday of the National Football League regular season.

Garoppolo, was traded to the 49ers by the Patriots last October, led San Francisco to a ideal 5-0 record down the stretch last season.

"I didn't see him getting frustrated", Smith said. He faced plenty of pressure, highlighted by DeForest Buckner and his 2½ sacks, and there were a handful of awkward-looking plays produced by the Vikings. "Just a tough way to end it".

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COMEBACK COMPLETE: Cook had 16 carries for 40 yards and six catches for 55 yards, a productive return to live action after tearing the ACL in his left knee about 11 months earlier. "We went against a very good defense, and we all didn't play as good as we could", 49ers coach Kyle Shanahan said. "Efficient. Doesn't make a lot of mistakes". He said Cousins was "locked in" from the start. "I think he did an admirable job".

Cousins, who signed a three-year, $84 million, fully guaranteed contract with the Vikings this spring, clearly savored his first regular season contest at U.S. Bank Stadium, where the Vikings are 15-3, including the playoffs since it opened.

"We were rolling there toward the end", Kittle said. Probably ran a bit too far with my arms out. Fred Zamberletti, the team's original athletic trainer who died last week at age 86, was honored with a pregame moment of silence. The Vikings also staged a 20th anniversary tribute to the 1998 squad that went 15-1 and reached the NFC championship game. Running back Robert Smith, one of 28 former players on hand for a halftime introduction, received the loudest ovation. He focused on the current team at the end of his speech. "You see that he's starting to get scared".

49ers: Goodwin hurt his right quadriceps in the first quarter and didn't return. With three backups on the OL already on the inactive list, rookie Mike McGlinchey had to move from RT to RG with Garry Gilliam taking his place. Hughes then cruised into the end zone for a touchdown.

Mackensie Alexander (ankle) missed Week 1 as well.

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